The probability of developing diabetes is 25% higher than others. Those who inherited two copies of the mutation had a 50% higher risk than normal people. Researchers have found that nearly half of people with closer Indian ancestry (including Latinos) carry this high-risk mutation. In addition, about 20% of East Asians carry this mutation, but this gene mutation is very rare in European and African populations. Test ELISA kit "Previously, most genetic studies used samples from people of European or Asian descent, which is likely to miss part of the SIGMA project in other races (Slim Initiative for Genomic Medicine for the Americas), verifying some Diabetes risk factor, and found an important new risk gene SLC16A11. They pointed out that the distribution of SLC16A11 mutations is unusual. Humans first originated in Africa, so almost all common human gene mutations appear in the African population. However, Common SLC16A11 mutations in the Indian population, but rarely occur in African and European populations. Further genomic analysis revealed that the SLC16A11 sequence associated with type 2 diabetes comes from the Neanderthal genome. Inherited Neanderthal Special people's genes are very common. At present, in people outside Africa, about 1% -2% of the genome sequence is derived from Neanderthals.
This is the first time people have discovered that the SLC16A11 gene is related to human diseases, and its function is not yet understood. The article provides some clues to explain its possible association with type 2 diabetes. The article points out that the gene family to which SLC16A11 belongs is responsible for encoding proteins that transport metabolites. SLC16A11 is expressed in the endoplasmic reticulum of liver cells. The researchers found that changing the level of SLC16A11 protein and detecting the ELISA kit can affect the amount of a type of fat, which is related to the risk of diabetes. Based on this, they speculated that SLC16A11 may be involved in transporting an unknown metabolite, and this metabolite can affect the fat level in cells, increase the risk of type 2 diabetes, identify the substance transported by this protein, and analyze it for glycerol. Effects of triester metabolism. They hope that by analyzing the pathogenesis of type 2 diabetes, they can develop new drugs that can effectively treat the disease.
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