On December 9, the international academic journal Nature Methods published the latest research results of the research team led by Researcher Pei Duanqing and Researcher Pan Guangjin of Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences-"Using patient urine cells Obtain neural stem cells ".
They studied the introduction of some stem cell factors into the cells isolated from the patient's urine by special means and cultivated them with a special induction medium, and successfully transformed the patient's urine cells into functional neural stem cells. These neural stem cells transformed from urine cells can be expanded in vitro and differentiated into mature neurons and keratinocytes in the human body under appropriate conditions. In further animal model transplantation experiments, it can survive and integrate into the host's brain environment.
Nerve injury and neurodegenerative diseases such as spinal cord injury, Parkinson's disease, brain injury, etc. due to poor regeneration of nerve cells, there is currently no effective treatment. Obtaining and transplanting patient-specific nerve cells can replace the nerve cells that have been damaged by the patient themselves to achieve the purpose of curing such neurological diseases. However, under normal circumstances, it is difficult to obtain and expand the patient's own nerve cells in vitro for clinical treatment. The research results of Pei Duanqing and Pan Guangjin effectively solved this problem, and provided a highly practical technical means and approach for obtaining patient-specific neural stem cells for transplantation therapy, which is expected to play a role in future clinical applications. Important role.
Fred Rusty Gage, a well-known neurobiologist, academician of the American Academy of Sciences, and professor of the Salk Institute, commented on this: "This is a major breakthrough in the field of stem cells, especially the use of non-viral systems to obtain urine cells from patients Neural stem cells with the ability to proliferate and differentiate in vivo and in vivo have important value in the field of stem cells. "
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