Recently, researcher Zhang Xiaoling of the Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences recently published a review article entitled Uptake mechanisms of non-viral gene delivery. In the authoritative journal Journal of Controlled Release.
Gene (molecular) therapy is an important area where breakthroughs can be made in the treatment of major human diseases. However, traditionally, viral vectors used for gene delivery have been questioned for their safety when used as drugs, making it difficult to be widely used clinically. Although some chemically synthesized non-viral gene carriers are superior to viral vectors in terms of safety, because they are difficult to effectively deliver genes to target cells in the body as gene drugs and are difficult to be efficiently absorbed by cells, the gene delivery efficiency has always been It has embarked on a clinical bottleneck.
In recent years, Xiang Shengnan, a graduate student in the Department of Cellular and Molecular Biology of the Institute of Health, has conducted a series of research work in the field of research and development of non-viral gene delivery systems and the treatment of bone-related diseases under the guidance of Zhang Xiaoling. This review combined with the research results, focused on the biological mechanism of non-viral gene delivery system being absorbed and absorbed by cells and related research progress, designed a more efficient non-viral gene delivery system for biologists and pharmacists in the future Provides important theoretical references.
Schematic diagram of various cell endocytosis pathways of non-viral vectors
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